PubMed Articles

Bovine colostrum treats cryptosporidiosis in boy with AIDS

Abstract: Lactobin-R is a commercial hyperimmune bovine colostrum with potent anticryptosporidial activity. It was administered to a 4 year old child with AIDS and severe diarrhoea associated with cryptosporidiosis. There was significant clinical improvement in the diarrhoea and permanent elimination of the parasite from the gut as assessed through serial jejunal...Read More »

Clinical Use of Bovine Colostrum

Abstract The nutritional value of milk is largely undisputed. Colostrum, the first milk produced by mammals after parturition, has been thoroughly studied on recent years, after confirming its superior nutritional and protective value when compared to milk. Initially, colostrum was used clinically as a vehicle for passive immunity transfer. It is...Read More »

Immune Components of Colostrum and Milk—A Historical Perspective

Abstract: Key developments in the understanding of the immune functions of milk and colostrum are reviewed, focusing on their proteinaceous components. The topics covered include the immunoglobulins, immune cells, immunomodulatory substances, and antimicrobial proteins. The contributions of new technologies and the introduction of fresh approaches from other fields are highlighted, as...Read More »

Peptide therapy and the gastroenterologist:

Abstract: Peptide therapy and the gastroenterologist: Colostrum is the specialized milk produced for the first few days following parturition. It is much richer in immunoglobulins, antimicrobial peptides and growth factors than the subsequent mature milk. In this article, some of these constituents of human and bovine colostrum in comparison with mature milk...Read More »

Colostrum can modulate post-op inflammatory response

Abstract: Several studies demonstrated acute inflammatory response following traumatic injury. Inflammatory response during surgical interventions was verified by a significant increase of endotoxin plasma levels and a decrease of the endotoxin neutralizing capacity (ENC). However, the incidence of elevated endotoxin levels was significantly higher (89%) than detected bacterial translocation (35%). Thus...Read More »

Bovine colostrum whey to release bioactive glycans

Abstract: EndoBI-1 is a recently isolated endo-β-N-acetylglucosaminidase, which cleaves the N-N′-diacetyl chitobiose moiety found in the N-glycan core of high mannose, hybrid and complex N-glycans. These N-glycans have selective prebiotic activity for a key infant gut microbe, Bifidobacterium longum subsp. infantis. The broad specificity of EndoBI-1 suggests the enzyme may be...Read More »

Colostrum alleviates immune mediated colitis

Background: Gut-derived bacterial endotoxin is an important cofactor in the pathogenesis of IBD. Regulatory T cells (Tregs) are essential for maintenance of peripheral tolerance and can prevent and alleviate IBD. To determine the immune modulatory effect of anti-LPS enriched hyperimmune colostrum, its ability to induce Tregs and alleviate immune mediated colitis. Methods: Immune-mediated...Read More »

Bovine Colostrum Supplementation:Salivary IgA

Bovine Colostrum Supplementation:Secretory IgA in saliva (s-IgA) is a potential mucosal immune correlate of upper respiratory tract infection (URTI) status. Nutritional supplements may improve mucosal immunity, and could be beneficial to athletes who are at increased risk of URTI. In this study, 35 distance runners (15 female, 20 male, age 35...Read More »

Bovine Colostrum and Murine Lymphoma Cells

DISCUSSION: Bovine Colostrum and Murine Lymphoma Cells UDP-Ga1NAc:polypeptide N-acetylgalactosaminyltransferase purified to homogeneity from bovine colostrum is a monomer of approximately 70,000 daltons as determined by both SDS-PAGE and gel filtration chromatography. An antibody raised against the purified 70,000-dalton enzyme precipitates the enzyme activity as well as the radiolabeled protein. The difference in...Read More »

Milk-derived proteins and peptides in clinical trials.

Summary Clinical trials are reviewed, involving proteins and peptides derived from milk (predominantly bovine), with the exception of lactoferrin, which will be the subject of another article. The most explored milk fraction is α-lactalbumin (LA), which is often applied with glycomacropeptide (GMP) – a casein degradation product. These milk constituents are...Read More »

Performance in Elite Field Hockey Players: Effect of Bovine Colostrum Supplementation

In a double-blind, randomized, placebo-controlled study, we investigated the effect of 8 weeks of supplementation with bovine colostrum (Intact™) on body composition and exercise performance (5 10-m sprint, vertical jump, shuttlerun test, and suicide test). Seventeen female and 18 male elite field hockey players, including players from the Dutch national...Read More »

Colostrum Science