Immune Components of Colostrum and Milk—A Historical Perspective

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Abstract: Key developments in the understanding of the immune functions of milk and colostrum are reviewed, focusing on their proteinaceous components. The topics covered include the immunoglobulins, immune cells, immunomodulatory substances, and antimicrobial proteins. The contributions of new technologies and the introduction of fresh approaches from other fields are highlighted,…
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Peptide therapy and the gastroenterologist:

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Abstract: Peptide therapy and the gastroenterologist: Colostrum is the specialized milk produced for the first few days following parturition. It is much richer in immunoglobulins, antimicrobial peptides and growth factors than the subsequent mature milk. In this article, some of these constituents of human and bovine colostrum in comparison with mature…
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Colostrum can modulate post-op inflammatory response

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Abstract: Several studies demonstrated acute inflammatory response following traumatic injury. Inflammatory response during surgical interventions was verified by a significant increase of endotoxin plasma levels and a decrease of the endotoxin neutralizing capacity (ENC). However, the incidence of elevated endotoxin levels was significantly higher (89%) than detected bacterial translocation (35%).…
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Bovine colostrum whey to release bioactive glycans

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Abstract: EndoBI-1 is a recently isolated endo-β-N-acetylglucosaminidase, which cleaves the N-N′-diacetyl chitobiose moiety found in the N-glycan core of high mannose, hybrid and complex N-glycans. These N-glycans have selective prebiotic activity for a key infant gut microbe, Bifidobacterium longum subsp. infantis. The broad specificity of EndoBI-1 suggests the enzyme may…
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Colostrum alleviates immune mediated colitis

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Background: Gut-derived bacterial endotoxin is an important cofactor in the pathogenesis of IBD. Regulatory T cells (Tregs) are essential for maintenance of peripheral tolerance and can prevent and alleviate IBD. To determine the immune modulatory effect of anti-LPS enriched hyperimmune colostrum, its ability to induce Tregs and alleviate immune mediated…
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Bovine Colostrum Supplementation:Salivary IgA

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Bovine Colostrum Supplementation:Secretory IgA in saliva (s-IgA) is a potential mucosal immune correlate of upper respiratory tract infection (URTI) status. Nutritional supplements may improve mucosal immunity, and could be beneficial to athletes who are at increased risk of URTI. In this study, 35 distance runners (15 female, 20 male, age…
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Bovine Colostrum and Murine Lymphoma Cells

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DISCUSSION: Bovine Colostrum and Murine Lymphoma Cells UDP-Ga1NAc:polypeptide N-acetylgalactosaminyltransferase purified to homogeneity from bovine colostrum is a monomer of approximately 70,000 daltons as determined by both SDS-PAGE and gel filtration chromatography. An antibody raised against the purified 70,000-dalton enzyme precipitates the enzyme activity as well as the radiolabeled protein. The difference…
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Bovine colostrum is a health food supplement which prevents NSAID induced gut damage

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Abstract BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) are effective for arthritis but cause gastrointestinal injury. Bovine colostrum is a rich source of growth factors and is marketed as a health food supplement. AIMS To examine whether spray dried, defatted colostrum or milk preparations could reduce gastrointestinal injury caused by indomethacin. METHODS…
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