Nutriceutical bovine colostrum-Heavy Exercise

Nutriceutical bovine colostrum-Heavy Exercise

The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes.

Am J Physiol Gastrointest Liver Physiol 300: G477–G484, 2011.

First published December 9, 2010; doi:10.1152/ajpgi.00281.2010.

—Heavy exercise causes gut symptoms and, in extreme cases, “heat stroke” partially due to increased intestinal permeability of luminal toxins. We examined bovine colostrum, a natural source of growth factors, as a potential moderator of such effects. Twelve volunteers completed a double-blind, placebo-controlled, crossover protocol (14 days colostrum/placebo) prior to standardized exercise. Gut permeability utilized 5 h urinary lactulose-to-rhamnose ratios. In vitro studies (T84, HT29, NCM460 human colon cell lines) examined colostrum effects on temperature-induced apoptosis (active caspase-3 and 9, Bax, Bcl-2), heat shock protein 70 (HSP70) expression and epithelial electrical resistance.

In both study arms, exercise increased blood lactate, heart rate, core temperature (mean 1.4°C rise) by similar amounts. Gut hormone profiles were similar in both arms although GLP-1 levels rose following exercise in the placebo but not the colostrum arm (P 0.026). Intestinal permeability in the placebo arm increased 2.5-fold following exercise (0.38 0.012 baseline, to 0.92 0.014, P  0.01), whereas colostrum truncated rise by 80% (0.38 0.012 baseline to 0.49 0.017) following exercise. In vitro apoptosis increased by 47– 65% in response to increasing temperature by 2°C. This effect was truncated by 60% if colostrum was present (all P  0.01). Similar results were obtained examining epithelial resistance (colostrum truncated temperature-induced fall in resistance by 64%, P  0.01). Colostrum increased HSP70 expression at both 37 and 39°C (P  0.001) and was truncated by addition of an EGF receptor-neutralizing antibody. Temperature-induced increase in Bax and reduction in Bcl-2 was partially reversed by presence of colostrum. Colostrum may have value in enhancing athletic performance and preventing heat stroke. 

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Tania Marchbank,1 Glen Davison,2 Jemma R. Oakes,2 Mohammad A. Ghatei,3 Michael Patterson,3 Mary Pat Moyer,4 and Raymond J. Playford1 1 Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine, Queen Mary University of London, London; 2 Department of Sport and Exercise Science, Aberystwyth University, Aberystwyth; 3 Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom; and 4 INCELL Corporation, San Antonio, Texas